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Metal-free decarboxylative C(sp<sup>3</sup>)–C(sp<sup>3</sup>) bond formation for the synthesis of unnatural amino acids and peptides <i>via</i> convergent paired electrolysis enabled radical–radical cross-coupling

Zenghui Ye, Na Chen, Hong Zhang, Yanqi Wu, Fengzhi Zhang

2024Green Chemistry13 citationsDOI

Abstract

Herein, we present the first metal-free decarboxylative C(sp 3 )–C(sp 3 ) cross-coupling of glycine derivatives with redox-active esters through highly atom and energy economical convergent paired electrolysis enabled radical–radical cross-coupling.

Topics & Concepts

ChemistryElectrolysisRadicalDecarboxylationRadical substitutionRadical ionMetalAmino acidCombinatorial chemistryOrganic chemistryMedicinal chemistryElectrolyteCatalysisBiochemistryElectrodePhysical chemistryIonRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques
Metal-free decarboxylative C(sp<sup>3</sup>)–C(sp<sup>3</sup>) bond formation for the synthesis of unnatural amino acids and peptides <i>via</i> convergent paired electrolysis enabled radical–radical cross-coupling | Litcius