A pH-responsive guanidino-based covalent organic framework nanodrugs for enhanced neuroprotection against subarachnoid hemorrhage by targeting NLRP3 inflammasome
Yang Li, Si Zhang, Qinghua Luo, Hong Shu, Wentao Xu, Xinyi Zhu, Xinyi Zhu, Ping Hu, Yanze Wu, Lei Shu, Junzhe Liu, Min Luo, Wei Tu, Haocheng Liu, Shigang Lv, Lı Wang, Xingen Zhu, Xingen Zhu, Wenping Zhu, Tengfeng Yan
Topics & Concepts
PyroptosisNanocarriersInflammasomeNeuroprotectionNeuroinflammationPharmacologyIn vivoMedicineCaspase 1Blood–brain barrierMaterials scienceDrug deliverySubarachnoid hemorrhageInflammationNanotechnologyDrugAnesthesiaImmunologyBiologyInternal medicineCentral nervous systemBiotechnologyIntracerebral and Subarachnoid Hemorrhage ResearchCerebrospinal fluid and hydrocephalusHeme Oxygenase-1 and Carbon Monoxide