Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis
Anne Piantadosi, Shibani S. Mukerji, Simon Ye, Michael J. Leone, Lisa M. Freimark, Daniel Park, Gordon Adams, Jacob E. Lemieux, Sanjat Kanjilal, Isaac H. Solomon, Asim Ahmed, Robert H. Goldstein, Vijay Ganesh, Bridget Ostrem, Kaelyn C. Cummins, Jesse Thon, Cormac M. Kinsella, Eric Rosenberg, Matthew P. Frosch, Marcia B. Goldberg, Tracey Cho, Pardis Sabeti
Abstract
= 24) CNS viral infection from a single center in New England and evaluated enhanced methods to improve the detection of CNS pathogens, including those not traditionally identified in the CNS by nucleic acid detection. Overall, our work helps elucidate how mNGS can become integrated into the diagnostic toolkit for CNS infections.
Topics & Concepts
MetagenomicsEncephalitisMeningitisPathogenVirusVirologyMedicineBiologyBacterial meningitisWorkflowViral encephalitisIntensive care medicineComputational biologyImmunologyComputer sciencePediatricsGeneBiochemistryDatabaseRespiratory viral infections researchVirology and Viral DiseasesViral Infections and Immunology Research