Role of fibroblast autophagy and proliferation in skin anti-aging
Yantong Lu, Guangjuan Pan, Zhiying Wei, Yaohua Li, Xiaojiao Pan
Abstract
Skin, as the outermost protective barrier of the body, becomes damaged with age and exposure to external stimuli. Dermal fibroblasts age and undergo apoptosis, which decreases collagen, collagen fibers, elastic fibers, hyaluronic acid, etc., leading skin to loss of elasticity and appearance of wrinkles. Skin aging is complex, involving several biological reactions，and various treatment methods are used to treat it. This review focuses on the importance of autophagy and cell proliferation in skin anti-aging, summarizes research progress on skin anti-aging by regulating autophagy and promoting the proliferation of dermal fibroblasts, and discusses future directions on skin anti-aging research. • Both promoting and inhibiting autophagy can prevent skin aging. • Promoting fibroblast proliferation is a good way to treat skin aging. • The combined use of different traditional anti-aging drugs can enhance the anti-aging effect of the skin.