Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes
Elaine Tseng, Heather Eng, Jian Lin, Matthew A. Cerny, David A. Tess, Theunis C. Goosen, R. Scott Obach
Topics & Concepts
CYP3ACytochrome P450MicrosomePharmacokineticsDrug metabolismDrugPharmacologyPhysiologically based pharmacokinetic modellingChemistryIn vitroBiologyMetabolismBiochemistryPharmacogenetics and Drug MetabolismDrug Transport and Resistance MechanismsStatistical Methods in Clinical Trials