Postinfectious Epigenetic Immune Modifications — A Double-Edged Sword
Andrew R. DiNardo, Mihai G. Netea, Daniel M. Musher
Abstract
Antigen-nonspecific host defenses are altered by infections, with epigenetic changes in the effector cells of natural immunity. Some of these changes enhance immune responses, and some interfere with them. The success of certain vaccination approaches may depend on finding a way to reverse the detrimental epigenetic effects of previous infection.
Topics & Concepts
EpigeneticsImmune systemEffectorImmunityBiologyImmunologySWORDVaccinationAntigenGeneticsGeneComputer scienceOperating systemImmune responses and vaccinationsEpigenetics and DNA MethylationImmune cells in cancer