Design, synthesis, anticancer activity, molecular docking and ADME studies of novel methylsulfonyl indole-benzimidazoles in comparison with ethylsulfonyl counterparts
Fikriye Zengin Karadayı, Murat Yaman, Mehmet Murat Kışla, Özlen Konu, Zeynep Ateş‐Alagöz
Abstract
Specific sidechain modifications on the indole-benzimidazole scaffold play fundamental roles for determining molecule's affinity against ERα and its anti-cancer activity.
Topics & Concepts
ChemistryBenzimidazoleADMEIndole testCombinatorial chemistryDocking (animal)ScaffoldComputational biologyStereochemistryBiochemistryIn vitroOrganic chemistryMedicineBiologyBiomedical engineeringNursingSynthesis and biological activityComputational Drug Discovery MethodsClick Chemistry and Applications