Gut Microbiota and Lung Cancer: A Mendelian Randomization Study
Huaqiang Zhou, Jiaqing Liu, Jiayi Shen, Wenfeng Fang, Li Zhang
Abstract
Gut microbiota deeply influences the host’s homeostasis. The imbalance of gut microbiota has been linked to common diseases, including various cancers.1 Nowadays, the role of gut microbiota in cancer immunotherapies also sparked the interest of researchers.2 There is a growing attention in targeting these microbiotas for cancer treatment. However, the interactions among drugs, gut microbiota, and cancer are complex and a deeper understanding of microbiome-cancer interactions is critical.3 Though several studies have mentioned the association between gut microbiota and lung cancer,2,4 robust epidemiologic evidence was able to discern that this causal relationship does not exist.
Topics & Concepts
Mendelian randomizationLung cancerMendelian inheritanceGut floraBiologyRandomizationMedicineInternal medicineGeneticsOncologyComputational biologyEvolutionary biologyClinical trialImmunologyGeneGenotypeGenetic variantsGut microbiota and healthCancer-related molecular mechanisms researchHelicobacter pylori-related gastroenterology studies