Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice
Yangyang Duan, Ye Tao, Zhe Qu, Yuewen Chen, Abigail Miranda, Xiaopu Zhou, Ka-Chun Lok, Yu Chen, Amy K.Y. Fu, Viviana Gradinaru, Nancy Y. Ip
Topics & Concepts
PresenilinAmyloid precursor proteinBiologyAmyloid betaAlzheimer's diseaseGenetically modified mouseBACE1-ASDementiaAmyloid (mycology)TransgeneNeuroscienceGeneGeneticsMedicineDiseasePathologyCRISPR and Genetic EngineeringRNA regulation and diseaseRetinal Development and Disorders