Tropical postbiotics alleviate the disorders in the gut microbiota and kidney damage induced by ochratoxin A exposure
Shuaiming Jiang, Lingwei Du, Zhao Qian, Shunyong Su, Shi Huang, Jiachao Zhang
Abstract
, elevating detrimental metabolites and inflammation. Also, OTA inhibited the Nrf2/HO-1 pathway, reducing kidney ROS elimination and leading to cellular ferroptosis and subsequent kidney damage. Postbiotics mitigate OTA's effects by downregulating the abundance of the assimilatory sulfate reduction IV pathway and virulence factors associated with iron uptake and relieving the inhibition of OTA on Nrf2/HO-1, restoring ROS-clearing capabilities and thereby alleviating chronic OTA-induced kidney damage. Understanding the OTA-gut-kidney link provides new approaches for preventing kidney damage, with postbiotics showing promise as a preventive treatment.
Topics & Concepts
Ochratoxin AKidneyGut floraMicrobiomeMicrobiologyBiologyFood scienceMedicineBioinformaticsImmunologyInternal medicineMycotoxinSelenium in Biological SystemsMycotoxins in Agriculture and FoodParasitic Infections and Diagnostics