A novel electrochemical Hofmann-type rearrangement enables facile access to α-oxoisocyanates for the synthesis of <i>N</i>-carbamoylacetamides
Xinxin Zhao, Jian Wang, Dabo Guo, Wenmin Liu, Yongqi Yu, Wenguang Li, Ting Li, Ming Chen
Abstract
A novel electrochemical Hofmann-type rearrangement to convert α-oxoamides into α-oxoisocyanates that are compatible with various N , O -based nucleophiles to access N -carbamoylacetamides and N -acylcarbamates.
Topics & Concepts
ElectrochemistryCombinatorial chemistryChemistryType (biology)NanotechnologyMaterials scienceElectrodePhysical chemistryBiologyEcologyChemical Synthesis and AnalysisChemical Synthesis and ReactionsSulfur-Based Synthesis Techniques