Dynamic PET-facilitated modeling and high-dose rifampin regimens for <i>Staphylococcus aureus</i> orthopedic implant–associated infections
Oren Gordon, Donald Lee, Bessie Liu, Brooke Langevin, Alvaro A. Ordoñez, Dustin Dikeman, Babar Shafiq, John M. Thompson, Paul D. Sponseller, Kelly Flavahan, Martin A. Lodge, Steven P. Rowe, Robert F. Dannals, Camilo A. Ruiz-Bedoya, Timothy D. Read, Charles A. Peloquin, Nathan K. Archer, Lloyd Miller, Kimberly M. Davis, Jogarao Gobburu, Sanjay K. Jain
Abstract
Current rifampin dosing achieves subtherapeutic concentrations within S. aureus –infected bone, which can be overcome with higher rifampin dosing.
Topics & Concepts
Staphylococcus aureusMedicineVancomycinAntibioticsRifampicinRegimenPharmacokineticsStaphylococcal infectionsPharmacodynamicsMethicillin-resistant Staphylococcus aureusInternal medicineOsteomyelitisDosingPharmacologyMicrobiologySurgeryBiologyBacteriaGeneticsOrthopedic Infections and TreatmentsAntimicrobial Resistance in StaphylococcusInfectious Diseases and Tuberculosis