Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study
Phil J. Greer, Peter J. Lee, Pedram Paragomi, Kim Stello, Anna Evans Phillips, Phil A. Hart, Cate Speake, Adam Lacy‐Hulbert, David C. Whitcomb, Georgios I. Papachristou
2022American Journal of Physiology-Gastrointestinal and Liver Physiology27 citationsDOIOpen Access PDF
Abstract
In this study, we showed that the proinflammatory cytokine response in SAP is an early event, with subsequent downregulation of proinflammatory cytokines beginning at day 1 of symptom onset. Our findings underscore the importance of enrolling subjects very early in the disease course when conducting studies to investigate early immune events of SAP; this current study also serves as an important reference for the design of future biomarker studies and therapeutic trials in SAP.
Topics & Concepts
Proinflammatory cytokineObservational studyBiomarkerMedicineAcute pancreatitisCytokineImmune systemImmunologyContext (archaeology)DiseaseInternal medicineBiologyInflammationBiochemistryPaleontologyPancreatitis Pathology and TreatmentPancreatic and Hepatic Oncology ResearchGastrointestinal disorders and treatments