Distinct distribution patterns of exercise-induced natural killer cell mobilization into the circulation and tumor tissue of patients with prostate cancer
Alexander Schenk, Tobias Esser, Sergen Belen, Nadira Gunasekara, Niklas Joisten, Matteo Winker, Lea Weike, Wilhelm Bloch, Axel Heidenreich, Jan Herden, Heike Löser, Sabine Oganesian, Sebastian Theurich, Carsten Watzl, Philipp Zimmer
Abstract
The mobilization and activation of natural killer (NK) cells have been proposed as key mechanisms promoting anti-oncogenic effects of physical exercise. Although mouse models have proven that physical exercise recruits NK cells to tumor tissue and inhibits tumor growth, this preclinical finding has not been transferred to the clinical setting yet. In this first-in-human study, we found that physical exercise mobilizes and redistributes NK cells, especially those with a cytotoxic phenotype, in line with preclinical models. However, physical exercise did not increase NK cell tumor infiltrates. Future studies should carefully distinguish between acute and chronic exercise modalities and should be encouraged to investigate more immune-responsive tumor entities.