Puerarin extends the lifespan of <i>Drosophila melanogaster</i> by activating autophagy
Ai-Wen Kang, Chi Sun, Haitao Li, Kun Zhong, Xuhui Zeng, Zhifeng Gu, Bingqian Li, Xiaoning Zhang, Jianlin Gao, Tianxing Chen
Abstract
Puerarin extends longevity of flies by improving climbing activity, ATP production, and stress resistance but repressing fecundity. Puerarin promotes lysosome-involved autophagy via inhibiting TOR phosphorylation, resulting in longevity of flies.
Topics & Concepts
PuerarinAutophagyDrosophila melanogasterLongevityBiologyProtein kinase ALysosomeAMPKATG5FOXO3AdenosineCell biologyBiochemistryKinasePhosphorylationGeneticsGeneMedicineEnzymeProtein kinase BAlternative medicineApoptosisPathologyGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapySirtuins and Resveratrol in Medicine