Design, synthesis and biological evaluation of 2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline derivatives as EGFR inhibitors
Xuemei Qin, Leifu Yang, Peng Liu, Lifang Yang, Linmeng Chen, Liming Hu, Mingguo Jiang
Topics & Concepts
QuinazolineChemistryEpidermal growth factor receptorEGFR inhibitorsIC50Cell cultureTyrosine kinaseDocking (animal)ErlotinibCancer researchKinasePharmacologyGefitinibLung cancerMTT assayCytotoxicityTyrosine-kinase inhibitorCell growthIn vitroBiochemistryStereochemistryCancerReceptorBiologyMedicineInternal medicineNursingGeneticsQuinazolinone synthesis and applicationsLung Cancer Treatments and MutationsCancer therapeutics and mechanisms