Oxidative Cascade Sulfonylation/Cyclisation of <i>N</i>‐Propargylindoles with Hantzsch Esters via Sulfur Dioxide Insertion
Jia‐Li Sui, Jian‐Hong Fan, Biquan Xiong, Kewen Tang, Yu Liu
Abstract
Abstract An oxidative sulfonylation/cyclisation of N ‐propargylindoles with Hantzsch esters through sulfur dioxide insertion has been developed. The method uses Na 2 S 2 O 5 as sulfur dioxide source along with 4‐alkyl‐substituted Hantzsch esters as radical precursors for accessing sulfonyl radicals, and allows for the synthesis of 2‐sulfonated 9 H ‐pyrrolo[1,2‐ a ]indoles.
Topics & Concepts
ChemistrySulfur dioxideOxidative phosphorylationSulfonylSulfurRadicalAlkylOrganic chemistryCascadeMedicinal chemistryBiochemistryChromatographySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods