The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase
Xinyuan Ding, Yuting Gu, Min Jin, Xin Guo, Sudong Xue, Caihong Tan, Jiefang Huang, Wanlin Yang, Mingxing Xue, Qianjun Zhou, Wenjuan Wang, Yanyun Zhang
Abstract
: It appears that UCHL1 promotes PEM resistance by upregulating TS in NSCLC cells, which mitigated DNA damage and cell cycle arrest. Thus, UCHL1 may be a therapeutic target for overcoming PEM resistance in NSCLC patients.
Topics & Concepts
Thymidylate synthasePemetrexedDeubiquitinating enzymeLung cancerCancer researchEnzymeChemistryCancerBiologyMedicineInternal medicineCisplatinUbiquitinBiochemistryGeneChemotherapyFluorouracilUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and Analysis