Fifty years on: Serotonin and depression
Sameer Jauhar, Philip J. Cowen, Michael Browning
Abstract
It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we summarise the evidence for the serotonin hypothesis of depression, focusing on psychopharmacology and molecular imaging, as well as systems-level neuroscience.
Topics & Concepts
PsychopharmacologySerotoninPsychologyDepression (economics)NeuroscienceNarrative reviewNarrativePsychiatryPsychotherapistClinical psychologyMedicineInternal medicinePhilosophyMacroeconomicsReceptorEconomicsLinguisticsTreatment of Major DepressionMental Health Research TopicsFunctional Brain Connectivity Studies