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Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis

Yang Xu, Xiao Ding, Yueqin Zhao, Yinyuan Wang, Xianxiang Dong, Zhenpeng Niu, Zhijia Gu, Jimin Fei, Yuhan Zhao, Xiao‐Jiang Hao, Yuhan Zhao, Xiao‐Jiang Hao

2025Science China Life Sciences8 citationsDOI

Topics & Concepts

TFEBAutophagyBiogenesisTFE3Cell biologyBasic helix-loop-helix leucine zipper transcription factorsCancer researchBiologyChemistryBiochemistryTranscription factorApoptosisGeneDNA-binding proteinEnhancerPhytochemical compounds biological activitiesUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research
Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis | Litcius