Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
Yusuke Hosoya, Junko Ohkanda
Abstract
Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid-liquid phase separations-which critically involve both intermolecular interactions between IDPs and their posttranslational modification-are analyzed to understand the potential of IDPs as new drug targets.
Topics & Concepts
Intrinsically disordered proteinsDrugComputational biologyDrug discoveryNanotechnologyChemistryBiologyBiophysicsBioinformaticsMaterials sciencePharmacologyRNA Research and SplicingProtein Structure and DynamicsWnt/β-catenin signaling in development and cancer