Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations
Cory W. Baumann, Dongmin Kwak, LaDora V. Thompson
Abstract
The underlying mechanisms contributing to the onset of frailty, its progression, and its mortality risk remain unknown. Recently, the two most common human frailty assessments were reverse-translated to mice. Here, we highlight the development of the mouse frailty phenotype, unique discoveries, experimental considerations, and future perspectives.
Topics & Concepts
PhenotypeBiologyLethalityGerontologyBioinformaticsMedicineComputational biologyGeneticsGeneFrailty in Older AdultsGenetics, Aging, and Longevity in Model OrganismsNutrition and Health in Aging