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Umpolung in a Pair of Cobalt(III) Terminal Imido/Imidyl Complexes

Weiqing Mao, Dominik Fehn, Frank W. Heinemann, Andreas Scheurer, Maurice van Gastel, Sergio A. V. Jannuzzi, Serena DeBeer, Dominik Munz, Karsten Meyer

2022Angewandte Chemie International Edition28 citationsDOIOpen Access PDF

Abstract

Abstract Reaction of the Co I complex [(TIMMN mes )Co I ](PF 6 ) ( 1 ) (TIMMN mes = t ris ‐[2‐(3‐mesityl‐ im idazolin‐2‐ylidene)‐ m ethyl]ami n e) with mesityl azide yields the Co III imide [(TIMMN mes )Co III (NMes)](PF 6 ) ( 2 ). Oxidation of 2 with [FeCp 2 ](PF 6 ) provides access to a rare Co III imidyl [(TIMMN mes )Co(NMes)](PF 6 ) 2 ( 3 ). Single‐crystal X‐ray diffractometry and EPR spectroscopy confirm the molecular structure of 3 and its S = ground state. ENDOR, X‐ray absorption spectroscopy and computational analyses indicate a ligand‐based oxidation; thus, an imidyl‐radical electronic structure for 3 . Migratory insertion of one ancillary NHC to the imido ligand in 2 gives the Co I N ‐heterocyclic imine ( 4 ) within 12 h. Conversely, it takes merely 0.5 h for 3 to transform to the Co II congener ( 5 ). The migratory insertion in 2 occurs via a nucleophilic attack of the imido ligand at the NHC to give 4 , whereas in 3 , a nucleophilic attack of the NHC at the electrophilic imidyl ligand yields 5 . The reactivity shunt upon oxidation of 2 to 3 confirms an umpolung of the imido ligand.

Topics & Concepts

ChemistryUmpolungLigand (biochemistry)NucleophileElectrophileImineReactivity (psychology)Medicinal chemistryAzidePincer ligandStereochemistryPhotochemistryCrystallographyPincer movementOrganic chemistryCatalysisPathologyReceptorBiochemistryMedicineAlternative medicineN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods
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