Update on TDM (Therapeutic Drug Monitoring) with Ustekinumab, Vedolizumab and Tofacitinib in Inflammatory Bowel Disease
Sophie Restellini, Waqqas Afif
Abstract
The goal of therapeutic drug monitoring (TDM) is to optimize anti-TNF (tumor necrosis factor) biologic treatment in patients with inflammatory bowel disease (IBD). Although commercial assays are readily available for both ustekinumab and vedolizumab, the use of TDM with these newer biologic medications is at its infancy. The clinical utility of TDM with non-anti-TNF mechanisms of action is not clear. This review summarizes the latest available data on the pharmacokinetics of newer biologic and oral small molecules and highlights the threshold concentrations that have been associated with improved outcomes in IBD patients.
Topics & Concepts
VedolizumabMedicineTofacitinibUstekinumabTherapeutic drug monitoringInflammatory bowel diseaseDrugFingolimodTumor necrosis factor alphaCrohn's diseasePharmacokineticsAdalimumabIntensive care medicinePharmacologyDiseaseInternal medicineImmunologyRheumatoid arthritisMultiple sclerosisInflammatory Bowel DiseaseMicroscopic ColitisPregnancy and Medication Impact