Mixing Mg-MOF-74 with Zn-MOF-74: A Facile Pathway of Controlling the Pharmacokinetic Release Rate of Curcumin
Shane Lawson, Andrew Siemers, Jason Kostlenick, Qasim Al‐Naddaf, Kyle Newport, Ali A. Rownaghi, Fateme Rezaei
Abstract
Recently, metal–organic frameworks (MOFs) have been widely employed as potential drug-delivery platforms; however, most studies have focused on the initial aspects of material development and have made little progress toward using MOFs as a means of controlling the pharmacokinetic rate of drug delivery. Nevertheless, it was recently determined that MOFs with highly soluble metal centers impart faster pharmacokinetic properties, so it stands to reason that combining two MOFs with different metal center solubilities could be used to control the pharmacokinetic release rate. To this end, in this study we varied the ratio of Mg-MOF-74 and Zn-MOF-74 between 80:20, 60:40, 40:60, and 20:80 wt % Mg:Zn to control the pharmacokinetic release rate of 30 wt % curcumin. The drug loading was characterized by using Fourier transform infrared spectroscopy and N2 physisorption, where it was confirmed that curcumin was impregnated successfully. More importantly, the drug delivery experiments in phosphate buffered saline from 0 to 24 h at 37.4 °C revealed that increasing the Mg-MOF-74 concentration enhanced both the raw amount of curcumin delivered and the pharmacokinetic rate of drug delivery. Specifically looking at the rate of drug delivery, drug diffusion constants of 0.17, 0.23, 0.24, and 0.26 h1/2 were calculated for the 20:80, 40:60, 60:40, and 80:20 Mg–Zn-MOF-74 samples, respectively, which indicated the profound relationship between the Mg-MOF-74 loading and the rate of curcumin delivery. In this regard, this study successfully demonstrated a potential pathway of controlling the pharmacokinetic rate of drug release from MOFs which can be considered a promising advancement in pharmacological medicine.