Fluoro‐Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors
Marco Colella, Arianna Tota, Yusuke Takahashi, Ryosuke Higuma, Susumu Ishikawa, Leonardo Degennaro, Renzo Luisi, Aiichiro Nagaki
Abstract
Abstract The external quenching method based on flow microreactors allows the generation and use of short‐lived fluoro‐substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.
Topics & Concepts
MethyllithiumMicroreactorReagentChemistryQuenching (fluorescence)Flow chemistryMoleculeCombinatorial chemistryContinuous flowPhotochemistryComputational chemistryNanotechnologyOrganic chemistryCatalysisMaterials scienceFluorescenceBiochemical engineeringPhysicsQuantum mechanicsEngineeringInnovative Microfluidic and Catalytic Techniques InnovationChemical Synthesis and AnalysisFluorine in Organic Chemistry