Angiotensin AT1 receptor antagonism by losartan stimulates adipocyte browning via induction of apelin
Dong Young Kim, Mi Jin Choi, Tae Kyung Ko, Na Hyun Lee, Ok‐Hee Kim, Hyae Gyeong Cheon
Abstract
receptor antagonism by losartan promotes the browning of white adipocytes via the induction of apelin expression. Therefore, apelin modulation may be an effective strategy for the treatment of obesity and its related metabolic disorders.
Topics & Concepts
LosartanAntagonismApelinAngiotensin II receptor type 1Angiotensin IIAdipocyteEndocrinologyInternal medicineRenin–angiotensin systemChemistryReceptorPharmacologyAngiotensin receptorBiologyMedicineAdipose tissueBlood pressureApelin-related biomedical researchLipid metabolism and disordersCardiovascular, Neuropeptides, and Oxidative Stress Research