Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane
Nils Frank, Jeremy Nugent, Bethany R. Shire, Helena D. Pickford, Patrick Rabe, Alistair J. Sterling, Tryfon Zarganes‐Tzitzikas, Thomas Grimes, Amber L. Thompson, Russell C. Smith, Christopher J. Schofield, Paul E. Brennan, Fernanda Duarte, Edward A. Anderson
Topics & Concepts
PropellaneChemistryADMEBicyclic moleculeMetabolic stabilityStereochemistryHeteroatomSubstituentRing (chemistry)Combinatorial chemistryOrganic chemistryIn vitroBiochemistryComputational Drug Discovery MethodsFree Radicals and AntioxidantsPhotochromic and Fluorescence Chemistry