Litcius/Paper detail

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Nils Frank, Jeremy Nugent, Bethany R. Shire, Helena D. Pickford, Patrick Rabe, Alistair J. Sterling, Tryfon Zarganes‐Tzitzikas, Thomas Grimes, Amber L. Thompson, Russell C. Smith, Christopher J. Schofield, Paul E. Brennan, Fernanda Duarte, Edward A. Anderson

2022Nature225 citationsDOIOpen Access PDF

Topics & Concepts

PropellaneChemistryADMEBicyclic moleculeMetabolic stabilityStereochemistryHeteroatomSubstituentRing (chemistry)Combinatorial chemistryOrganic chemistryIn vitroBiochemistryComputational Drug Discovery MethodsFree Radicals and AntioxidantsPhotochromic and Fluorescence Chemistry