Selective treatment of intracellular bacterial infections using host cell-targeted bioorthogonal nanozymes
Joseph Hardie, Jessa Marie Makabenta, Aarohi Gupta, Rui Huang, Roberto Cao‐Milán, Ritabrita Goswami, Xianzhi Zhang, Parvati Abdulpurkar, Michelle E. Farkas, Vincent M. Rotello
Abstract
Macrophage-targeted bioorthogonal nanozyme designed to generate antibiotics at the site of infection. Nanozymes had targeted uptake by macrophages through mannose functionalization, then generated antibiotics to specifically kill infectious bacteria.
Topics & Concepts
Bioorthogonal chemistryAntibioticsIntracellularBacteriaChemistryMicrobiologyMacrophageBiologyCombinatorial chemistryBiochemistryClick chemistryIn vitroGeneticsAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesNanoplatforms for cancer theranostics