Hyperthermia-induced stellate cell deactivation to enhance dual chemo and pH-responsive photothermal therapy for pancreatic cancers
Qinglian Hu, Minjie Xu, Jiayu Feng, Hui Xie, Jingyu Li, Ying He, Guping Tang, Bing Guo
Abstract
Lipid nanoparticles loaded with dual gemcitabine and pH-sensitive photothermal drug generate local hyperthermia, assist in deactivating pancreatic stellate cells, enhance drug penetration and significantly boost chemo-phototherapy outcomes.
Topics & Concepts
Photothermal therapyHyperthermiaCancer researchHepatic stellate cellPancreatic cancerHyperthermia therapyDual roleMedicineMaterials scienceChemistryNanotechnologyPathologyCancerInternal medicineCombinatorial chemistryNanoplatforms for cancer theranosticsPancreatic and Hepatic Oncology ResearchExtracellular vesicles in disease