Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface
Devan Diwanji, Raphael Trenker, Tarjani Thaker, Feng Wang, David A. Agard, Kliment A. Verba, Natalia Jura
Topics & Concepts
Allosteric regulationDimerPertuzumabChemistryConformational changeMutantBiophysicsLigand (biochemistry)Plasma protein bindingEpidermal growth factor receptorReceptorTrastuzumabStereochemistryBiochemistryBiologyCancerGeneGeneticsBreast cancerOrganic chemistryMonoclonal and Polyclonal Antibodies ResearchHER2/EGFR in Cancer ResearchCell Adhesion Molecules Research