Inborn Errors of Immunity Causing Pediatric Susceptibility to Fungal Diseases
Peter Olbrich, Donald C. Vinh
Abstract
Inborn errors of immunity are a heterogeneous group of genetically determined disorders that compromise the immune system, predisposing patients to infections, autoinflammatory/autoimmunity syndromes, atopy/allergies, lymphoproliferative disorders, and/or malignancies. An emerging manifestation is susceptibility to fungal disease, caused by yeasts or moulds, in a superficial or invasive fashion. In this review, we describe recent advances in the field of inborn errors of immunity associated with increased susceptibility to fungal disease.
Topics & Concepts
ImmunologyImmunityAtopyDiseaseAllergyAutoimmunityMedicineImmune systemLymphoproliferative disordersBiologyPathologyLymphomaImmunodeficiency and Autoimmune DisordersBlood disorders and treatmentsFungal Infections and Studies