Dimeric PKM2 induces ferroptosis from intestinal ischemia/reperfusion in mice by histone H4 lysine 12 lactylation-mediated HMGB1 transcription activation through the lactic acid/p300 axis

Zan Liu, Yuxiang Zhou, Ming Li, Zhenghui Xiao, Zitong Zhao, Yong Li

2025Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease6 citationsDOI

Topics & Concepts

PKM2Gene knockdownIn vivoChemistryHMGB1Molecular biologyCell biologyCancer researchBiologyBiochemistryPyruvate kinaseApoptosisMetabolismGlycolysisReceptorBiotechnologyFerroptosis and cancer prognosisImmune cells in cancerCancer, Hypoxia, and Metabolism