A novel neuroprotective peptide YVYAETY identified and screened from<i>Flammulina velutipes</i>protein hydrolysates attenuates scopolamine-induced cognitive impairment in mice
Yutong Dong, Qiuhui Hu, Liyan Zhao, Gaoxing Ma, Ning Ma, Junmiao Zhang, Yang Ji, Li Liu
Abstract
. The behavioral tests showed that YVYAETY improved scopolamine-induced cognitive impairment in mice. YVYAETY also alleviated neuron damage including neuron vacuolation and pyknotic nuclei in the hippocampus. Furthermore, it significantly inhibited oxidative stress and suppressed the activation of the Nrf2 pathway. Therefore, this study revealed that YVYAETY had the potential to serve as a novel neuroprotective agent.
Topics & Concepts
FlammulinaNeuroprotectionHydrolysateScopolaminePeptideCognitive impairmentPharmacologyChemistryMedicineBiologyCognitionFood scienceBiochemistryNeuroscienceMushroomHydrolysisGenomics, phytochemicals, and oxidative stressGDF15 and Related BiomarkersMacrophage Migration Inhibitory Factor