P-sort: an open-source software for cerebellar neurophysiology
Ehsan Sedaghat-Nejad, Mohammad Amin Fakharian, Jay S. Pi, Paul Hage, Yoshiko Kojima, Robi Soetedjo, Shogo Ohmae, Javier F. Medina, Reza Shadmehr
Abstract
Algorithms that perform spike sorting depend on waveforms to cluster spikes. However, a cerebellar Purkinje-cell produces two types of spikes; simple and complex spikes. A complex spike coincides with the suppression of generating simple spikes. Here, we recorded neurophysiological data from three species and developed a spike analysis software named P-sort that relies on this statistical property to improve both the detection and the attribution of simple and complex spikes in the cerebellum.
Topics & Concepts
Spike (software development)NeurophysiologyComputer scienceSpike sortingsortNeuroscienceCerebellumProperty (philosophy)Simple (philosophy)SortingPurkinje cellArtificial intelligencePattern recognition (psychology)AlgorithmPsychologyInformation retrievalEpistemologySoftware engineeringPhilosophyVestibular and auditory disordersNeural dynamics and brain functionBlind Source Separation Techniques