Rupture of blood clots: Mechanics and pathophysiology
Valerie Tutwiler, Jaspreet Singh, Rustem I. Litvinov, J.L. Bassani, Prashant K. Purohit, John W. Weisel
Abstract
. Finite element (FE) simulations using fibrin material models that account for forced protein unfolding independently supported this measured toughness and showed that breaking of fibers ahead the crack at a critical stretch is the mechanism of rupture of blood clots, including thrombotic embolization.
Topics & Concepts
FibrinBlood flowThrombosisMedicineCoagulationBiomedical engineeringPathologyCardiologySurgeryInternal medicineImmunologyBlood properties and coagulationTrauma, Hemostasis, Coagulopathy, ResuscitationElasticity and Material Modeling