Cobalt‐Catalyzed Facial‐Selective Hydroalkylation of Cyclopropenes
Zhilin Zhang, Zhen Li, Yuantai Xu, Lu Yu, Jian Kuang, Yan Li, Jia‐Wang Wang, Changlin Tian, Xi Lu, Yao Fu
Abstract
Cyclopropene hydrofunctionalization has been a promising strategy for accessing multi-substituted cyclopropanes; however, cyclopropene hydroalkylation remains underdeveloped. Herein, we report a low-valent CoH-catalyzed facial-selective cyclopropene hydroalkylation to access multi-substituted cyclopropanes. This reaction exhibits a broad substrate scope of alkyl halides and cyclopropenes and tolerates many functional groups. Moderate-to-good facial-selectivity is obtained without any directing groups. Mechanism studies provide evidence that alkyl radicals are generated from alkyl halides and irreversible CoH insertion is responsible for the facial-selectivity. Our preliminary exploration demonstrates that asymmetric cyclopropene hydroalkylation can be realized without conspicuous auxiliary groups.