Aqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketones <i>via</i> Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation
Pengqian Luan, Yunting Liu, Yongxing Li, Ran Chen, Chen Huang, Jing Gao, Frank Hollmann, Yanjun Jiang
Abstract
Aqueous chemoenzymatic two-step one-pot enantioselective synthesis of tertiary α-aryl cycloketones <italic>via</italic> Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation was developed.
Topics & Concepts
Enantioselective synthesisArylCatalysisChemistryAsymmetric hydrogenationAqueous solutionEnzymeOrganic chemistryAqueous mediumStereochemistryCombinatorial chemistryAlkylAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization Methods