Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41
Alexandra Maslennikova, Natalia Kruglova, С. В. Калиниченко, Dmitriy Komkov, М. В. Шепелев, Dmitriy Golubev, Andrei E. Siniavin, Andrei N. Vzorov, Alexander Filatov, Dmitriy Mazurov
Abstract
HIV is a human lentivirus that infects CD4-positive immune cells and, when left untreated, manifests in the fatal disease known as AIDS. Antiretroviral therapy (ART) does not leading to viral clearance, and HIV persists in the organism as a latent provirus.
Topics & Concepts
Heptad repeatGp41PeptideMolecular biologyEpitopeBiologyVirologyChemistryPeptide sequenceAntibodyBiochemistryGeneticsGeneHIV Research and TreatmentCRISPR and Genetic Engineeringvaccines and immunoinformatics approaches