Effect of Methylmercury Binding on the Peroxide-Reducing Potential of Cysteine and Selenocysteine
Andrea Madabeni, Pablo A. Nogara, Marco Bortoli, João Batista Teixeira da Rocha, Laura Orian
Abstract
binding promotes oxidation of the S or Se nucleus, suggesting that chalcogenoxide formation might occur in the toxified enzyme, even if the actual rate of peroxide reduction is almost certainly lowered as suggested by comparison with fully deprotonated amino acids models.
Topics & Concepts
ChemistrySelenocysteineThioredoxin reductaseCysteinePeroxideAmino acidDeprotonationProtonationEnzymeStereochemistryBiochemistryThioredoxinOrganic chemistryIonRedox biology and oxidative stressSelenium in Biological SystemsSulfur Compounds in Biology