Structural insights for rational design of new PIM-1 kinase inhibitors based on 3,5-disubstituted indole derivatives: An integrative computational approach
Hafez Razmazma, Ali Ebrahimi, Mohammad Hashemi
Topics & Concepts
Quantitative structure–activity relationshipComputational biologyKinaseDocking (animal)Indole testStructural similaritySerineRational designStereochemistryChemistryBiologyBiochemistryEnzymeGeneticsMedicineNursingCancer Mechanisms and TherapySynthesis and biological activitySynthesis and bioactivity of alkaloids