Mitochondrial Damage Mediated by miR-1 Overexpression in Cancer Stem Cells
Song Zhang, Cuilian Liu, Xiaobo Zhang
Abstract
(Mol Ther Nucleic Acids. 18, 938–953; December 6, 2019) In the originally published version of Figure 2I, an incorrect image for the BCSC-GPD2-siRNA-scrambled panel was inadvertently included. This error has no bearing on the interpretation of the results, nor does it influence the conclusions of the work. Figure 2I has been corrected online. The authors regret this error.Figure 2IThe Induction of miR-1-Mediated Mitochondrial Damage by Targeting GPD2 and MINOS1 Genes (Original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Mitochondrial Damage Mediated by miR-1 Overexpression in Cancer Stem CellsZhang et al.Molecular Therapy - Nucleic AcidsOctober 24, 2019In BriefIt is well known that cells rely on mitochondrial respiration for survival. However, the effect of microRNAs (miRNAs) on mitochondria of cells has not been extensively explored. Our results indicated that the overexpression of a miRNA (miR-1) could destroy mitochondria of cancer stem cells. miR-1 was downregulated in melanoma stem cells (MSCs) and breast cancer stem cells (BCSCs) compared with cancer non-stem cells. However, the upregulation of miR-1 in cancer non-stem cells did not induce mitochondrial damage. Full-Text PDF Open Access