New pyrazolopyridine and pyrazolothiazole-based compounds as anti-proliferative agents targeting c-Met kinase inhibition: design, synthesis, biological evaluation, and computational studies
Zahra M. Al-Amshany, Eman M. Algamdi, Ismail M. M. Othman, Manal M. Anwar, Eman S. Nossier
Abstract
ADME studies were also performed for 5a and 5b to predict their physicochemical and pharmacokinetic characteristics.
Topics & Concepts
ChemistryIC50CytotoxicityApoptosisErlotinibThiazoleStereochemistryDocking (animal)CabozantinibPharmacologyCell growthTyrosine kinaseCell cycleKinaseCancer cellBiochemistryIn vitroCancerCancer researchSignal transductionBiologyReceptorEpidermal growth factor receptorVEGF receptorsMedicineNursingGeneticsLiver physiology and pathologyCancer Mechanisms and TherapyPI3K/AKT/mTOR signaling in cancer