The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6
Nicholas Denomme, April L. Lukowski, Jacob M. Hull, Margaret B. Jameson, Alexandra A. Bouza, Alison R. H. Narayan, Lori L. Isom
Topics & Concepts
NAV1Sodium channelTetrodotoxinNav1.5Patch clampHeterologous expressionChemistrySodium channel blockerNeuroscienceProtein subunitBiophysicsPharmacologyCell biologyElectrophysiologyBiologySodiumBiochemistryRecombinant DNAGeneOrganic chemistryIon channel regulation and functionMarine Toxins and Detection MethodsNicotinic Acetylcholine Receptors Study