Population Pharmacokinetics of Esketamine Nasal Spray and its Metabolite Noresketamine in Healthy Subjects and Patients with Treatment-Resistant Depression
Carlos Pérez‐Ruixo, Stefaan Rossenu, Peter Zannikos, Partha Nandy, Jaskaran Singh, Wayne C. Drevets, Juan José Pérez Ruixo
Topics & Concepts
Nasal sprayMedicinePharmacokineticsNONMEMVolume of distributionMucociliary clearanceNasal administrationAnesthesiaPopulationBioavailabilityInternal medicineGastroenterologyPharmacologyLungEnvironmental healthTreatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorPharmacology and Obesity Treatment