Sulfhydrylated albumin mitigates Acetaminophen-induced liver injury by restoring the integrated H2S-albumin thiol antioxidant network
Xin Wang, Yang Sui, Rui Jiang, Yijun Xu, Mika Suda, Jie Cheng, Yingyu Zhang, Zhuheng Shi, Jianglin Fan, Jian Yao
Abstract
S and Alb-SSH as integral components of a coordinated thiol antioxidant network that counteracts AILI. Supplementation with Alb-SSH represents a promising therapeutic strategy for AILI and other oxidative stress-associated diseases.
Topics & Concepts
AlbuminAcetaminophenLiver injuryMedicineChemistryPharmacologyBiochemistryLiver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and ProtectionLiver Disease and Transplantation