Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation <i>in vitro</i> and <i>in vivo</i>
Zheng Sun, Xuejing Gu, Hao Teng, Jiali Liu, Rongrong Gao, Yanli Li, Bin Yu, Hui Xu
Abstract
drug release from MLX-MS could be observed, bivariate correlation analysis. All the findings demonstrated that local administration of MLX-MS can prolong the action time of MLX and reduce side effects, thus would be a promising preparation for the treatment of arthritis.
Topics & Concepts
MeloxicamIn vivoPharmacologyPharmacokineticsMaterials scienceChemistryMedicineBiotechnologyBiologyAdvanced Drug Delivery SystemsAdvancements in Transdermal Drug DeliveryAntimicrobial Peptides and Activities