Design, synthesis, and biological evaluation of novel (4-(1,2,4-oxadiazol-5-yl)phenyl)-2-aminoacetamide derivatives as multifunctional agents for the treatment of Alzheimer's disease
Tongtong Liu, Shiming Chen, Jiyu Du, Siqi Xing, Rong Li, Zeng Li
Topics & Concepts
ChemistryButyrylcholinesteraseNeuroprotectionPotencyIC50NeuroinflammationLead compoundPharmacologyDPPHReactive oxygen speciesAntioxidantStereochemistryBiochemistryIn vitroInflammationAchéAcetylcholinesteraseEnzymeImmunologyMedicineBiologyCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments