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High-resolution, noninvasive single-cell lineage tracing in mice and humans based on DNA methylation epimutations

Mengyang Chen, Rong Fu, Yiqian Chen, Li Li, Shou‐Wen Wang

2025Nature Methods34 citationsDOI

Topics & Concepts

Lineage (genetic)BiologyDNA methylationCell lineageSomatic cellPhenotypeHaematopoiesisComputational biologyStem cellGeneGeneticsEvolutionary biologyCell biologyCellular differentiationGene expressionSingle-cell and spatial transcriptomicsEpigenetics and DNA MethylationCancer Genomics and Diagnostics
High-resolution, noninvasive single-cell lineage tracing in mice and humans based on DNA methylation epimutations | Litcius