The Odilorhabdin Antibiotic Biosynthetic Cluster and Acetyltransferase Self-Resistance Locus Are Niche and Species Specific
Anne Lanois-Nouri, Lucile Pantel, Jun Fu, Jessica Houard, Jean-Claude Ogier, Yury S. Polikanov, Emilie Racine, Hailong Wang, Sophie Gaudriault, Alain Givaudan, Maxime Gualtiéri
Abstract
Odilorhabdins (ODLs) constitute a novel antibiotic family with promising properties for treating problematic multidrug-resistant Gram-negative bacterial infections. ODLs are 10-mer linear cationic peptides inhibiting bacterial translation by binding to the small subunit of the ribosome.
Topics & Concepts
BiologyAntibiotic resistanceGeneMicrobiologyGeneticsAntibioticsEntomopathogenic Microorganisms in Pest ControlInsect and Pesticide ResearchInsect symbiosis and bacterial influences